中文Uhlobo Olutsha lwe-Coronavirus eNxulumene 501Y-V2 yaseMzantsi Afrika
Ngomhla we-18 kaDisemba, 2020, uMzantsi Afrika wafumanisa i-501Y-V2 eguqukayo ye-coronavirus entsha.Ngoku inguqu yaseMzantsi Afrika isasazeke kumazwe angaphezu kwama-20.Iimvavanyo zibonise ukuba ngaphezulu kwe-New Corona-virus ye-Mutants inokuthwala ezinye iintlobo ze-New Coronavirus ze-K417N/T, i-E484K kunye neenguqu ze-N501Y ezinokunciphisa amandla okunciphisa isitofu sokugonya esibangelwa yi-plasma.Nangona kunjalo, xa kuthelekiswa nereferensi yegenome iWuh01 (inombolo yolandelelwano MN908947), i-501Y.V2 yolandelelwano lwegenome eguqukileyo yaseMzantsi Afrika inama-23 eenucleotide ezahlukeneyo.Inokuguqulwa okufanayo kwe-N501Y njenge-B.1.1.7 sub-type ye-B.1.1.7 eguquguqukayo, kodwa iqulethe utshintsho kwiindawo ezimbini eziphambili ze-E484K kunye ne-K417N ye-protein ye-S eneziphumo ezibalulekileyo ezinokuthi zikwazi ukusuleleka kwintsholongwane.
ICoronavirus eNtsha yiNtsholongwane ye-RNA enemisonto enye, apho utshintsho lweGenome luhlala lukhona.Ukufunyaniswa kwenjongo enye kunokukhokelela ngokulula ekuphosweni kweisampulu ezinomthamo wentsholongwane egazini osezantsi kunye nohlobo lwentsholongwane eguqukileyo.Ireyithi yokuphonononga kwakhona kwi-positive eyodwa ekuchongeni okujoliswe kuyo, inokufikelela ngaphezu kwe-10%, enokunyusa umsebenzi kunye nokwandisa ixesha lokuxilongwa.Ukufunyanwa kwezinto ezininzi ekujoliswe kuzo kunye nokuqinisekiswa okufanayo kweziphumo zethagethi nganye kunokunyusa izinga lokufumanisa kwaye kuququzelele ukuxilongwa kwangaphambili.
Umzobo 1. Umzobo wesicwangciso sendlela entsha yosulelo lweCoronavirus
Entsha yeCoronavirus Mutant B.1.1.7 yaseBritane
Ngomhla wama-26 kuDisemba, ngo-2020, iphepha lokuqala lezenzululwazi le-B.1.1.7 Strain lapapashwa kwi-intanethi.I-Institute of Hygiene University yaseLondon yase-UK kunye neZifo zeTropiki, iqinisekisile ukuba i-B.1.1.7 Strain iyakwazi ukusasazeka kunezinye iintlobo, ezazingaphezulu kwe-56% (95% CI 50-74%).Ngenxa yokuba olu hlobo lutsha lwe-mutant lunamandla acacileyo okusasaza, kuye kwaba nzima ukulawula i-COVID-19.Ngosuku olulandelayo, iYunivesithi yaseBirmingham eUnited Kingdom yafaka inqaku ngeMedRxiv.Uphononongo lufumene ukuba inani le-ORF1ab kunye ne-N iikopi zentsholongwane ye-virus kwizigulane ezosulelwe yi-B.1.1.7 ye-mutant strain (S-gene dropout) yanda kakhulu;lo mcimbi wawubekwe iliso kuluntu.Eli nqaku libonisa ukuba izigulane ezosulelwe yi-B.1.1.7 ye-B.
Umzobo 2. Ulandelelwano lokuguqulwa kwegenome oluqulethwe kwi-coronavirus mutant strain B.1.1.7 yaseBritane.
Umfanekiso 3. Utshintsho lwe-N501Y lwenzekile eBritane naseMzantsi AfrikaUkwahluka
Ikhithi yokujonga yezantlukwano ezitsha zeCoronavirus
I-Chuangkun Biotech Inc. iphuhlise ngempumelelo ikhithi yokubona i-B.1.1.7 kunye ne-501Y-V2 entsha ye-coronavirus eyahlukileyo.
Izinto eziluncedo zale mveliso: ubuntununtunu obuphezulu, ukuchongwa ngaxeshanye kweethagethi ezi-4, eziquka iindawo eziguqukayo eziphambili ze-B.1.1.7 ze-mutant strain kunye ne-501Y.V2 yaseMzantsi Afrika ye-mutant strain.Le khithi inokubona ngaxeshanye i-N501Y, i-HV69-70del, i-E484K iisayithi zokuguqula kunye ne-coronavirus entsha gene;Uvavanyo olukhawulezayo: kuthatha iyure enye kuphela imizuzu engama-30 ukusuka kwingqokelela yesampulu ukuya kwisiphumo.
Umzobo 4. Ukufunyanwa kwe-COVID-19 yaseBritani eyahlukayo yoAmplification Curve
Umzobo 5. Ukufunyanwa kwe-COVID-19 yaseMzantsi Afrika eyahluka-hlukeneyo yoAmplification Curve
Umfanekiso 6. Udidi lwasendle lwegophe lokukhulisa i-coronavirus entsha
Akukacaci ukuba olu tshintsho luqokelela njani ifuthe elitsha lexesha elide lobhubhani we-COVID-19 ilungelo.Kodwa oku kusikhumbuza ukuba olu tshintsho lunokuchaphazela ukusebenza kokugonywa kwendalo kunye nokhuseleko oluziswa lugonyo.Ikwasikhumbuza ukuba kufuneka siqhubeke sibeka iliso kwi-coronavirus entsha ixesha elide kwaye sihlaziye isitofu sokugonya se-COVID-19 ukujongana nokuvela kwe-coronavirus entsha.
Ixesha lokuposa: Mar-12-2021