I-CHKBiotech iphuhlise ngempumelelo ikhithi yokufumanisa iintlobo ezintsha ze-coronavirus

Uhlobo Olutsha lwe-Coronavirus eNxulumene 501Y-V2 yaseMzantsi Afrika
Ngomhla we-18 kaDisemba, 2020, uMzantsi Afrika wafumanisa i-501Y-V2 eguqukayo ye-coronavirus entsha.Ngoku inguqu yaseMzantsi Afrika isasazeke kumazwe angaphezu kwama-20.Iimvavanyo zibonise ukuba ngaphezulu kwe-New Corona-virus ye-Mutants inokuthwala ezinye iintlobo ze-New Coronavirus ze-K417N/T, i-E484K kunye neenguqu ze-N501Y ezinokunciphisa amandla okunciphisa isitofu sokugonya esibangelwa yi-plasma.Nangona kunjalo, xa kuthelekiswa nereferensi yegenome iWuh01 (inombolo yolandelelwano MN908947), i-501Y.V2 yolandelelwano lwegenome eguqukileyo yaseMzantsi Afrika inama-23 eenucleotide ezahlukeneyo.Inokuguqulwa okufanayo kwe-N501Y njenge-B.1.1.7 sub-type ye-B.1.1.7 eguquguqukayo, kodwa iqulethe utshintsho kwiindawo ezimbini eziphambili ze-E484K kunye ne-K417N ye-protein ye-S eneziphumo ezibalulekileyo ezinokuthi zikwazi ukusuleleka kwintsholongwane.

ICoronavirus eNtsha yiNtsholongwane ye-RNA enemisonto enye, apho utshintsho lweGenome luhlala lukhona.Ukufunyaniswa kwenjongo enye kunokukhokelela ngokulula ekuphosweni kweisampulu ezinomthamo wentsholongwane egazini osezantsi kunye nohlobo lwentsholongwane eguqukileyo.Ireyithi yokuphonononga kwakhona kwi-positive eyodwa ekuchongeni okujoliswe kuyo, inokufikelela ngaphezu kwe-10%, enokunyusa umsebenzi kunye nokwandisa ixesha lokuxilongwa.Ukufunyanwa kwezinto ezininzi ekujoliswe kuzo kunye nokuqinisekiswa okufanayo kweziphumo zethagethi nganye kunokunyusa izinga lokufumanisa kwaye kuququzelele ukuxilongwa kwangaphambili.

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Umzobo 1. Umzobo wesicwangciso sendlela entsha yosulelo lweCoronavirus

Entsha yeCoronavirus Mutant B.1.1.7 yaseBritane
Ngomhla wama-26 kuDisemba, ngo-2020, iphepha lokuqala lezenzululwazi le-B.1.1.7 Strain lapapashwa kwi-intanethi.I-Institute of Hygiene University yaseLondon yase-UK kunye neZifo zeTropiki, iqinisekisile ukuba i-B.1.1.7 Strain iyakwazi ukusasazeka kunezinye iintlobo, ezazingaphezulu kwe-56% (95% CI 50-74%).Ngenxa yokuba olu hlobo lutsha lwe-mutant lunamandla acacileyo okusasaza, kuye kwaba nzima ukulawula i-COVID-19.Ngosuku olulandelayo, iYunivesithi yaseBirmingham eUnited Kingdom yafaka inqaku ngeMedRxiv.Uphononongo lufumene ukuba inani le-ORF1ab kunye ne-N iikopi zentsholongwane ye-virus kwizigulane ezosulelwe yi-B.1.1.7 ye-mutant strain (S-gene dropout) yanda kakhulu;lo mcimbi wawubekwe iliso kuluntu.Eli nqaku libonisa ukuba izigulane ezosulelwe yi-B.1.1.7 ye-B.

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Umzobo 2. Ulandelelwano lokuguqulwa kwegenome oluqulethwe kwi-coronavirus mutant strain B.1.1.7 yaseBritane.

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Umfanekiso 3. Utshintsho lwe-N501Y lwenzekile eBritane naseMzantsi AfrikaUkwahluka

Ikhithi yokujonga yezantlukwano ezitsha zeCoronavirus
I-Chuangkun Biotech Inc. iphuhlise ngempumelelo ikhithi yokubona i-B.1.1.7 kunye ne-501Y-V2 entsha ye-coronavirus eyahlukileyo.

Izinto eziluncedo zale mveliso: ubuntununtunu obuphezulu, ukuchongwa ngaxeshanye kweethagethi ezi-4, eziquka iindawo eziguqukayo eziphambili ze-B.1.1.7 ze-mutant strain kunye ne-501Y.V2 yaseMzantsi Afrika ye-mutant strain.Le khithi inokubona ngaxeshanye i-N501Y, i-HV69-70del, i-E484K iisayithi zokuguqula kunye ne-coronavirus entsha gene;Uvavanyo olukhawulezayo: kuthatha iyure enye kuphela imizuzu engama-30 ukusuka kwingqokelela yesampulu ukuya kwisiphumo.

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Umzobo 4. Ukufunyanwa kwe-COVID-19 yaseBritani eyahlukayo yoAmplification Curve

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Umzobo 5. Ukufunyanwa kwe-COVID-19 yaseMzantsi Afrika eyahluka-hlukeneyo yoAmplification Curve

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Umfanekiso 6. Udidi lwasendle lwegophe lokukhulisa i-coronavirus entsha

Akukacaci ukuba olu tshintsho luqokelela njani ifuthe elitsha lexesha elide lobhubhani we-COVID-19 ilungelo.Kodwa oku kusikhumbuza ukuba olu tshintsho lunokuchaphazela ukusebenza kokugonywa kwendalo kunye nokhuseleko oluziswa lugonyo.Ikwasikhumbuza ukuba kufuneka siqhubeke sibeka iliso kwi-coronavirus entsha ixesha elide kwaye sihlaziye isitofu sokugonya se-COVID-19 ukujongana nokuvela kwe-coronavirus entsha.


Ixesha lokuposa: Mar-12-2021